Yasser, Han, Adrien, Ting, Bob, and Claire’s Paper in Proceedings of the National Academy of Sciences

Yasser, Han, Adrien, Ting, Bob, and Claire’s Paper on flexible organic reflectance oximeter arrays got published in Proceedings of the National Academy of Sciences. Congrats!!!

Paper title: A flexible organic reflectance oximeter array

Abstract: Transmission-mode pulse oximetry, the optical method for determining oxygen saturation in blood, is limited to only tissues that can be transilluminated, such as the earlobes and the fingers. The existing sensor configuration provides only single point measurements, lacking two-dimensional (2D) oxygenation mapping capability. Here, we demonstrate a novel flexible and printed sensor array composed of organic light-emitting diodes and organic photodiodes, which senses reflected light from tissue to determine the oxygen saturation. We use the reflectance oximeter array beyond the conventional sensing locations using a novel sensor configuration. The sensor is implemented to measure oxygen saturation on the forehead with 1.1% mean error and to create 2D oxygenation maps of adult forearms under pressure cuff-induced ischemia. In addition, we present mathematical models to determine oxygenation in the presence and absence of a pulsatile arterial blood signal. The mechanical flexibility, 2D oxygenation mapping capability, and the ability to place the sensor in various locations make the reflectance oximeter array promising for novel medical sensing applications such as monitoring of real-time chronic medical conditions as well as post-surgery recovery management of tissues, organs, and wounds.

Publication:

  • [PDF] [URL] Y. Khan, D. Han, A. Pierre, J. Ting, X. Wang, C. M. Lochner, G. Bovo, N. Yaacobi-Gross, C. Newsome, R. Wilson, and A. C. Arias, “A flexible organic reflectance oximeter array,” Proceedings of the National Academy of Sciences, 2018.

    [Abstract]

    The optical method to determine oxygen saturation in blood is limited to only tissues that can be transilluminated. The status quo provides a single-point measurement and lacks 2D oxygenation mapping capability. We use organic printed optoelectronics in a flexible array configuration that senses reflected light from tissue. Our reflectance oximeter is used beyond conventional sensing locations and accurately measures oxygen saturation on the forehead. In a full system implementation, coupled with a mathematical model, we create 2D oxygenation maps of adult forearms under pressure-cuff{\textendash}induced ischemia. Our skin-like flexible sensor system has the potential to transform oxygenation monitoring of tissues, wounds, skin grafts, and transplanted organs.Transmission-mode pulse oximetry, the optical method for determining oxygen saturation in blood, is limited to only tissues that can be transilluminated, such as the earlobes and the fingers. The existing sensor configuration provides only single-point measurements, lacking 2D oxygenation mapping capability. Here, we demonstrate a flexible and printed sensor array composed of organic light-emitting diodes and organic photodiodes, which senses reflected light from tissue to determine the oxygen saturation. We use the reflectance oximeter array beyond the conventional sensing locations. The sensor is implemented to measure oxygen saturation on the forehead with 1.1\% mean error and to create 2D oxygenation maps of adult forearms under pressure-cuff{\textendash}induced ischemia. In addition, we present mathematical models to determine oxygenation in the presence and absence of a pulsatile arterial blood signal. The mechanical flexibility, 2D oxygenation mapping capability, and the ability to place the sensor in various locations make the reflectance oximeter array promising for medical sensing applications such as monitoring of real-time chronic medical conditions as well as postsurgery recovery management of tissues, organs, and wounds.

    [Bibtex]

    @article {khan2018a,
    author = {Khan, Yasser and Han, Donggeon and Pierre, Adrien and Ting, Jonathan and Wang, Xingchun and Lochner, Claire M. and Bovo, Gianluca and Yaacobi-Gross, Nir and Newsome, Chris and Wilson, Richard and Arias, Ana C.},
    title = {A flexible organic reflectance oximeter array},
    year = {2018},
    doi = {10.1073/pnas.1813053115},
    publisher = {National Academy of Sciences},
    abstract = {The optical method to determine oxygen saturation in blood is limited to only tissues that can be transilluminated. The status quo provides a single-point measurement and lacks 2D oxygenation mapping capability. We use organic printed optoelectronics in a flexible array configuration that senses reflected light from tissue. Our reflectance oximeter is used beyond conventional sensing locations and accurately measures oxygen saturation on the forehead. In a full system implementation, coupled with a mathematical model, we create 2D oxygenation maps of adult forearms under pressure-cuff{\textendash}induced ischemia. Our skin-like flexible sensor system has the potential to transform oxygenation monitoring of tissues, wounds, skin grafts, and transplanted organs.Transmission-mode pulse oximetry, the optical method for determining oxygen saturation in blood, is limited to only tissues that can be transilluminated, such as the earlobes and the fingers. The existing sensor configuration provides only single-point measurements, lacking 2D oxygenation mapping capability. Here, we demonstrate a flexible and printed sensor array composed of organic light-emitting diodes and organic photodiodes, which senses reflected light from tissue to determine the oxygen saturation. We use the reflectance oximeter array beyond the conventional sensing locations. The sensor is implemented to measure oxygen saturation on the forehead with 1.1\% mean error and to create 2D oxygenation maps of adult forearms under pressure-cuff{\textendash}induced ischemia. In addition, we present mathematical models to determine oxygenation in the presence and absence of a pulsatile arterial blood signal. The mechanical flexibility, 2D oxygenation mapping capability, and the ability to place the sensor in various locations make the reflectance oximeter array promising for medical sensing applications such as monitoring of real-time chronic medical conditions as well as postsurgery recovery management of tissues, organs, and wounds.},
    issn = {0027-8424},
    URL = {http://www.pnas.org/content/early/2018/11/06/1813053115},
    eprint = {http://www.pnas.org/content/early/2018/11/06/1813053115.full.pdf},
    journal = {Proceedings of the National Academy of Sciences},
    thumbnail = {https://www.ocf.berkeley.edu/~arias/public/publications/files/khan2018a.png},
    pdf = {https://www.ocf.berkeley.edu/~arias/public/publications/files/khan2018a.pdf}
    }